Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling
Benjamin Le Gac, Marine Tournissac, Esther Belzic, Sandrine Picaud, Isabelle Dusart, Hédi Antoine Soula, Dongdong Li, Serge Charpak, Bruno Cauli
This study identifies that pyramidal cell firing induces arteriolar vasoconstriction via COX-2-derived prostaglandin E2 signaling, revealing a previously overlooked mechanism in neurovascular coupling.
eLife · Apr 23, 2025Peer-reviewedNeuroscience