Ariel A. Di Nardo

The paper shows that modulating perineuronal nets in the motor cortex of Parkinson's disease mice improves motor function when combined with environmental enrichment and training.

This study shows that OTX2 in parvalbumin interneurons of the piriform cortex affects their maturation and olfactory behavior in mice.

The paper compares molecular signatures of juvenile critical period plasticity and adult enhanced plasticity in parvalbumin cells, finding distinct translatomic profiles and condition-specific pathways.

This study shows that choroid plexus APP affects adult brain proliferation and behavior in mice, with reduced proliferation and cognitive deficits observed after APP overexpression.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

This study shows that OTX2 synthesized in the choroid plexus and secreted into cerebrospinal fluid regulates anxiety-like behaviors in mice through non-cell-autonomous mechanisms.

The paper examines diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex, finding increased PNN and PV staining intensity during the dark phase.

The paper shows that OTX2 non-cell autonomous activity in the retina affects inner retinal function and causes reduced visual acuity without altering retinal structure or photoreceptor physiology.

This study shows that PV interneurons regulate PNNs in the adult cortex through electrical activity, with silencing causing PNN regression and excitation having no effect.

This study shows that extracellular Pax6 non-cell autonomously regulates Cajal-Retzius cell migration in the developing mouse neocortex by affecting directionality, distance, and depth of migration.

The paper shows OTX2 secreted by the choroid plexus regulates adult neurogenesis by affecting astrocytes and extracellular matrix, reducing newborn neurons in the olfactory bulb.

The paper shows that OTX2 homeoprotein transfer regulates visual cortex plasticity in juvenile mice by modulating Gadd45b/g expression and epigenetic states.