Disruption of EGF feedback by intestinal tumors and neighboring cells in Drosophila
Sang Ngo, Jackson Liang, Yu‐Han Su, Lucy Erin O’Brien
This paper shows that APC-/- tumors in Drosophila disrupt EGF feedback by inducing Rho in both neighboring and tumor cells, leading to chronic EGF signaling and cancerous overgrowth.
bioRxiv · Jan 31, 2020 · PreprintDevelopmental Biology