Lucy Erin O’Brien

This study identifies lactic acid from gut microbes as a key factor improving Drosophila survival during starvation by enhancing oxidative phosphorylation.

This study shows that organ injury accelerates stem cell differentiation by altering a Notch-Delta lateral inhibition circuit, reducing feedback delays and increasing Delta ligand levels.

The paper investigates how stem cell progeny in Drosophila intestinal epithelium acquire barrier-forming structures through a transient niche, enabling their integration into the epithelial barrier.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

This paper shows that APC-/- tumors in Drosophila disrupt EGF feedback by inducing Rho in both neighboring and tumor cells, leading to chronic EGF signaling and cancerous overgrowth.

Bellymount allows long-term, non-invasive imaging of Drosophila abdominal organs and gut microbiota, enabling tracking of cellular and microbial dynamics over multiple days.

The paper shows that epithelial organ size is maintained through a feedback mechanism linking stem cell divisions to enterocyte apoptosis in Drosophila.

The paper develops two models to explain how stem cell scaling occurs during organ resizing in Drosophila midgut by linking commitment rate to stem cell proportion.