Computational design of monomeric Fc variants with distinct pH-responsive FcRn-binding profiles
Jung Ho Jeon, Hyejin Lee, Sanghyeon Choi, Seonghyuk Suh, Seong‐Bin Im, Yeon‐Gil Kim, Bo Mi Ku, Myung‐Ju Ahn, Bo-Seong Jeong, Byung‐Ha Oh
The paper computationally designs monomeric Fc variants with distinct pH-responsive FcRn-binding profiles, showing enhanced binding at acidic pH and weak binding at neutral pH.
bioRxiv · May 26, 2025 · PreprintBioengineering