Byung‐Ha Oh

This paper introduces K-Fold, a method that improves prediction of conformational changes in protein complexes by modeling structural transitions from unbound to bound states.

The paper develops an in silico-in vitro workflow to generate high-affinity antibodies targeting the KRAS(G12D)-MHC I complex, achieving nanomolar affinity and specific T cell activation.

This paper designs a potent Wnt surrogate specific for Fzd7 subtype members, showing strong binding affinity and functional activity in organoid formation and hair regeneration.

This paper computationally designs and experimentally validates a single-domain antibody that specifically recognizes a WT1 peptide-loaded class I MHC complex with high affinity and specificity.

The paper computationally designs monomeric Fc variants with distinct pH-responsive FcRn-binding profiles, showing enhanced binding at acidic pH and weak binding at neutral pH.

The paper designs modular biosensors using de novo protein switches that detect various analytes with high sensitivity and modularity.