Hyejin Lee

The paper develops an in silico-in vitro workflow to generate high-affinity antibodies targeting the KRAS(G12D)-MHC I complex, achieving nanomolar affinity and specific T cell activation.

This paper computationally designs and experimentally validates a single-domain antibody that specifically recognizes a WT1 peptide-loaded class I MHC complex with high affinity and specificity.

The paper computationally designs monomeric Fc variants with distinct pH-responsive FcRn-binding profiles, showing enhanced binding at acidic pH and weak binding at neutral pH.