Myung‐Ju Ahn

An integrated in silico-in vitro workflow for discovering high-affinity, selective antibodies to the KRAS(G12D)-MHC I complex

The paper develops an in silico-in vitro workflow to generate high-affinity antibodies targeting the KRAS(G12D)-MHC I complex, achieving nanomolar affinity and specific T cell activation.

Computational design of monomeric Fc variants with distinct pH-responsive FcRn-binding profiles

The paper computationally designs monomeric Fc variants with distinct pH-responsive FcRn-binding profiles, showing enhanced binding at acidic pH and weak binding at neutral pH.

Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer

This study links tumor and immune cell profiles in NSCLC patients to their response to immune checkpoint inhibitors, finding higher CD4+ regulatory T cells and NF-kB/STAT3 activity in non-responders.

Predicting Lung Cancer in Korean Never-Smokers with Polygenic Risk Scores

This study develops a lung cancer prediction model for Korean never-smokers using polygenic risk scores, finding higher odds ratios and improved AUC with PRSs.

JuLI: accurate detection of DNA fusions in clinical sequencing for precision oncology

JuLI improves DNA fusion detection in clinical sequencing by reducing false positives and increasing sensitivity, outperforming existing methods in high-depth sequencing.