Gut-Brain Hydraulics: Brain motion and CSF circulation is driven by mechanical coupling with the abdomen
C. Spencer Garborg, Beatrice Ghitti, Qingguang Zhang, Joseph M. Ricotta, Noah Frank, Sara J. Mueller, Denver I. Greenawalt, Kevin L. Turner, Ravi Teja Kedarasetti, Marceline Mostafa, Hyunseok Lee, Francesco Costanzo, Patrick J. Drew
This study shows brain motion in mice is driven by abdominal muscle contractions and linked to hydraulic fluid flow, impacting brain health through mechanical coupling with the abdomen.
Nature Neuroscience · Apr 27, 2026Peer-reviewedNeuroscience