Patrick J. Drew

The paper identifies ultrafast venous and sagittal sinus contractions in mice driven by abdominal pressure and mechanical coupling, affecting cerebral blood flow.

This study shows brain motion in mice is driven by abdominal muscle contractions and linked to hydraulic fluid flow, impacting brain health through mechanical coupling with the abdomen.

This study shows that type-I nNOS neurons regulate neural and vascular dynamics in the brain by altering activity patterns and blood volume responses.

This study shows alcohol consumption disrupts somatostatin signaling in the prelimbic prefrontal cortex of mice, with potential implications for alcohol use disorder treatment.

This study shows adolescent alcohol exposure in mice leads to sex-specific behavioral and neural changes, with females showing increased alcohol preference and males showing altered cellular excitability.

This paper introduces a transparent ultrasound transducer cranial window for integrating ultrasound neuromodulation and optical neuroimaging in awake mice, showing increased cerebral blood flow and hemoglobin with stimulation.

This study identifies age-related changes in cerebrovascular structure and function in the mouse brain, including reduced vascular length and increased tortuosity in specific regions.

This study investigates the role of somatostatin peptide signaling in the prelimbic cortex, showing it dampens cortical circuits and promotes exploratory behavior through specific physiological and pharmacological mechanisms.

The paper shows that in neonatal mice, sensory stimulation causes vasoconstriction only when mice are asleep, as arousal state changes override neurovascular coupling.

This study examines how pupil diameter and blinking correlate with cortical activity and hemodynamics across different arousal states in mice, finding strong relationships that can reliably indicate arousal state.

This study uses a poroelastic model to show that arteriolar dilation drives convective fluid flow in the brain, enhancing waste clearance during sleep and sensory activity.

The paper maps the spatial relationship between cerebrovasculature, pericytes, and neuronal cell types in mice to reveal how they support regional brain energy homeostasis.

This study investigates the origin of 1/f-like oxygenation fluctuations in the murine cortex and finds that they are driven by erythrocyte flow dynamics rather than neural activity.

Iliski computes transfer functions between signals using deconvolution and optimization algorithms, applied to neurovascular coupling data.

This study examines how cerebral hemodynamics change during different sleep states in mice, finding that hemodynamic responses during NREM and REM sleep are significantly larger than those evoked by sensory stimulation.

This study shows that functional hyperemia drives fluid exchange in the paravascular space by interacting with brain tissue deformability.

This study shows that oxygen-functionalized soots reduce olfactory progenitor cells in mice, potentially affecting CSF drainage and linking air pollution to neurodegenerative disease risk.

The paper uses simulations to show that NO degradation rates in blood and tissue drive vascular dynamics like vasodilation, constriction, and vasomotion.

This study uses fluid dynamic simulations to show that arterial pulsations cause oscillatory CSF motion, not directional pumping, and that directional flow results from pressure differences.

This study shows that locomotion increases cerebral oxygenation in mice, and this increase is linked to respiration rate and phase.

This study investigates the anatomical and physiological role of cerebrospinal fluid transport through the murine cribriform plate and finds that olfactory sensory nerves are critical for CSF outflow.

The paper identifies a small group of nitric oxide-producing neurons that control basal and evoked blood flow in the cortex, showing that hemodynamic signals are regulated by specific neuronal activity rather than overall population activity.