Francesco Costanzo

This study shows brain motion in mice is driven by abdominal muscle contractions and linked to hydraulic fluid flow, impacting brain health through mechanical coupling with the abdomen.

This study uses a poroelastic model to show that arteriolar dilation drives convective fluid flow in the brain, enhancing waste clearance during sleep and sensory activity.

This study shows that functional hyperemia drives fluid exchange in the paravascular space by interacting with brain tissue deformability.

This study uses fluid dynamic simulations to show that arterial pulsations cause oscillatory CSF motion, not directional pumping, and that directional flow results from pressure differences.