The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
Rodrigo Romero, Tinyi Chu, Tania J González-Robles, Perianne Smith, Yubin Xie, Harmanpreet Kaur, Sara Yoder, Huiyong Zhao, Chenyi Mao, Wenfei Kang, Maria V. Pulina, Kayla E. Lawrence, Anuradha Gopalan, Samir Zaidi, Kwangmin Yoo, , Charles L. Sawyers
This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.
Nature Cancer · Oct 11, 2024Peer-reviewedCancer Biology