Author

Wenfei Kang

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Ning FaniD· 4 shared Charles L. SawyersiD· 3 shared Elisa de StanchinaiD· 3 shared Eric RosiekiD· 3 shared Subhiksha NandakumariD· 3 shared Zhenghao CheniD· 3 shared Anuradha GopalaniD· 2 shared Chen Khuan WongiD· 2 shared

Activity by Year

2025-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

Ning FanORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD

Teng Han, Zhen Sun, Matthew Lange, Y Zoe Cho, Patrick D. McGillivray, Maren Büttner, Nathaniel R. Kastan, Subhiksha Nandakumar, HuiYong Zhao, Eralda Salataj, Sanyukta Oak, Linda E. Fong, Wenfei Kang, Ning Fan, Francesca Mazzoni, , Charles L. Sawyers

Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.

bioRxiv · Aug 23, 2026 · PreprintCancer Biology✦ In-depth digest

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development

Young Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz, Max Land, Roshan Sharma, Joseph Chan, Perianne Smith, Sanjay V. Kottapalli, Linda E. Fong, Zhenghao Chen, Eric Huttenlocher Bent, HuiYong Zhao, Elisa de Stanchina, Wenfei Kang, Shevin Narine, , Charles L. Sawyers

This study identifies an IL-1β/IL-6 signaling circuit in the tumor microenvironment that drives prostate cancer progression from pre-invasive to invasive stages.

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma

Emily A. Costa, Barbara Vaz de Mello, Corrin A. Wohlhieter, Subhiksha Nandakumar, Samuel Tischfield, Yingqian Ada Zhan, Harsha Sridhar, Dennis Kinyua, Elisa de Stanchina, Wenfei Kang, Ning Fan, Alister P. W. Funnell, John E. Lazar, Justin Jee, Irina Linkov, , Charles M. Rudin

The paper identifies SMARCA4/STK11/KEAP1 triple mutant lung adenocarcinoma as a poor prognosis subset and links it to TGF-β pathway activation.

Translational Oncology · Jul 20, 2026Peer-reviewedCancer Biology

Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening

Samir Zaidi, Maren Büttner, Weiran Feng, Caitlin Baxter, D. Henry Kates, Tiago Paiva Prudente, Diana Zakharova, Sanjoy Mehta, Subhiksha Nandakumar, Chen Khuan Wong, Hojin Lee, Pierre-Jacques Hamard, Wenfei Kang, Jungmin Choi, Ronan Chaligne, , Charles L. Sawyers

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

bioRxiv · May 8, 2026 · PreprintCancer Biology

Cell-Autonomous AR Dependence in Luminal Prostatic Epithelium Governs Survival and Lineage Plasticity

Dan Li, Naitao Wang, Wangxin Guo, Jude N. Owiredu, Woo Hyun Cho, Dana Schoeps, Shipeng Cheng, Hongjiong Zhang, Un In Chan, Chen Khuan Wong, V.R. Callychurn, Hongsu Wang, Wenfei Kang, Ning Fan, Hilda Amalia Pasolli, , Yu Chen

This study shows that luminal prostatic epithelial cells depend on AR signaling for survival and differentiation, and their loss triggers compensatory pathways and lineage plasticity.

bioRxiv · Feb 16, 2026 · PreprintCell Biology

Galectin-3 is a Nanotherapeutic Target in Graft-versus-Host Disease Mediated Kidney Injury

Magdalini Panagiotakopoulou, Ashley N. Sullivan, Kimon V. Argyropoulos, Anastasia I. Kousa, Logan R. Hillger, Kaitlyn Pierpont, Jorge Nunez, Eric Rosiek, Francesca Mazzoni, Wenfei Kang, Emma Grabarnik, Anastasiya Egorova, Brianna Gipson, Romina Ghale, Stephen B. Ruiz, , Daniel A. Heller

The paper identifies galectin-3 as a target for nanotherapeutic delivery of ruxolitinib to reduce GVHD-related kidney injury and systemic inflammation.

bioRxiv · Nov 19, 2025 · PreprintBioengineering