Jungmin Choi

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

This study identifies Hedgehog signaling as a key driver of intestinal stem cell regeneration by promoting the emergence of new Lgr5+ stem cells from non-Lgr5+ clones, distinct from existing self-renewal and dedifferentiation models.

The paper shows that ATG8a turnover via the Arg/N-degron pathway regulates autophagy and thermotolerance in Arabidopsis during heat stress.

The paper shows Erbin interacts with NHERF1 and Ezrin to stabilize a membrane HER2 signaling complex in HER2-positive breast cancer, enhancing HER2 stability and transforming ability.

This study uses longitudinal multi-omic analyses of a mouse model to show seizure evolution in West syndrome involves synaptic remodeling, gliosis, and proteomic/lipidomic changes over time.

This study develops a method to generate human anterior neural organoids (hANOs) and uses them to model microcephaly in Cohen syndrome by analyzing gene expression and cellular phenotypes.

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

This paper introduces a modular approach to create uniform forebrain assembloids that mimic the mature structure and functional connectivity of the human brain.

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.