Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation.
Ronja Larissa Schirrmann, Daniel Stowitschek, Malika Franziska Sutter, J-H Lee, Boyu Zhao, S Lee, Aylin Neyazi, Ben Felix Broesamle, Franziska Ginsberg, Pia Krammer, Ayline Kübler, Thomas Vogl, Helmut Wittkowski, Sarah Ahmad, B Krämer, , Maya Caroline Andre
This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.
bioRxiv · Mar 27, 2026 · PreprintImmunology