Emily Margaret Mace

This study identifies CXCR4 and CXCL12 as regulators of stromal-NK cell interactions that control NK cell adhesion, migration, and maturation in humans.

This paper identifies an allosteric checkpoint in CD16a that regulates NK cell ADCC independently of IgG-Fc binding, revealing a mechanism for modulating immune responses.

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.

The paper identifies a CDC45 variant causing immune disease with allelic bias, linking it to NK cell dysfunction and variable expressivity in a family.

The paper investigates cell-to-cell communication in Alzheimer's disease to characterize disease biology and suggest new avenues for therapeutic intervention.

This study uses MINFLUX nanoscopy to map CD16a spatial distribution in NK cells, revealing CD16a pairs and increased density at synapses during ADCC activation.

This study shows that PAG links to the actin cytoskeleton, and this interaction is essential for T cell synapse formation and cytotoxic function.

The paper examines immunosenescence trajectories in diverse populations, finding associations between immunological age and brain atrophy, while highlighting CMV status and genetic ancestry as key factors.

This study shows CD56/NCAM is essential for human NK cell migration by modulating actin dynamics and integrin turnover during movement on stromal cells.

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.

The paper introduces a quantitative model of innate immune activation regulation using Bayesian inference, revealing tradeoffs between precision and adaptation.