Author

Helmut Wittkowski

University Hospital MünsterORCID 0000-0001-6038-7460Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Alicja JózkowicziD· 1 shared Aljoscha Swoboda· 1 shared Anibh Martin DasiD· 1 shared Anja Seelhöfer· 1 shared Ann-Marie TobinskiiD· 1 shared Aylin Neyazi· 1 shared Ayline KübleriD· 1 shared B Krämer· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperMolecular Biology

Alicja JózkowiczORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 27, 2026

Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation.

Ronja Larissa Schirrmann, Daniel Stowitschek, Malika Franziska Sutter…·Maya Caroline Andre

This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.

DOI 10.64898/2026.03.25.714180

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 1, 2025

The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypes

Susanne Schleifenbaum, Aljoscha Swoboda, Johannes Dirks…·Christoph Kessel

This study compares how synovial fluid from systemic juvenile idiopathic arthritis (sJIA) and JIA patients influences T helper cell polarization, showing sJIA SF promotes a specific Tph phenotype linked to IL-1β, IL-18, and GM-CSF.

DOI 10.1101/2025.07.01.661738

humanproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 5, 2024

Treatment with 2-phospho-L-ascorbic acid mitigates biochemical phenotypes of heme oxygenase 1 deficiency

Lea-Sophie Berendes, Petra Schulze-Westhoff, Ann-Marie Tobinski…·Julien H. Park

This study shows that 2-phospho-L-ascorbic acid treatment improves mitochondrial function and reduces cytotoxicity in HO-1 deficient cells.

DOI 10.1101/2024.07.05.602073

humanexperimental assay

𝕏 PostBluesky