The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Pedro A. Mateos‐Gómez, Tatiana Kent, Sarah Deng, Shane McDevitt, Ekaterina Kashkina, Trung Hoàng, Richard T. Pomerantz, Agnel J. Sfeir
This study shows that the helicase domain of Polθ promotes alt-NHEJ by displacing RPA, leading to increased chromosomal translocations and reduced HR-mediated gene targeting.
Nature Structural & Molecular Biology · Oct 19, 2017Peer-reviewedGenetics