Functional classification of GNAI1 disorder variants in C. elegans uncovers conserved and cell-specific mechanisms of dysfunction
Rehab Salama, Eric Peet, Logan Morrione, Sarah Durant, Maxwell D. Seager, Madison Rennie, Suzanne Scarlata, Inna V. Nechipurenko
The paper evaluates seven GNAI1 disorder variants in C. elegans and human cells to determine their impact on ciliogenesis and neuronal function, identifying conserved and cell-specific mechanisms of dysfunction.
Genetics · Oct 7, 2025Peer-reviewedDevelopmental Biology