Paradoxic enhancement of mitochondrial capacity in aging-specific megakaryopoiesis from hematopoietic stem cells
Saran Chattopadhyaya, Stephanie Smith‐Berdan, Sarah Huerta, E. Camilla Forsberg
This study shows that aging-specific megakaryocyte progenitors have increased mitochondrial capacity, contrasting with aged hematopoietic stem cells, and that enhancing mitochondrial activity affects platelet production differently in young and old mice.
bioRxiv · Nov 10, 2025 · PreprintCell Biology