Author

Sarah S. Kappa

Baylor College of Medicine

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Bikesh Kumar NiralaiD· 1 shared Jason Todd YusteiniD· 1 shared Lyazat KurenbekovaiD· 1 shared Ryan Lane Shuck· 1 shared Tajhal Patel· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

Bikesh Kumar NiralaORCID

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1 paper

Recent·Most cited

MYC-Hyperactivated Osteosarcoma Models Exhibit Resistance to Cabozantinib plus TIGIT Blockade

Sarah S. Kappa, Tajhal Patel, Bikesh Kumar Nirala, Lyazat Kurenbekova, Ryan Lane Shuck, Jason Todd Yustein

This study evaluates the efficacy of cabozantinib plus TIGIT blockade in osteosarcoma models, finding improved outcomes in p53-driven tumors but resistance in MYC-hyperactivated models due to myeloid recruitment and ECM remodeling.

bioRxiv · Sep 26, 2026 · PreprintCancer Biology