Continuous DNA Methylation Deconvolution-Based Surrogate for B-Cell Differentiation State in CLL
Jeffrey R. Hage, Lauren M. Wainman, Fiyinfoluwa Kolawole, Fred Kolling, Pauline Patzke, Daniel K. Schoolcraft, Sarah Spracklin, Prabhjot Kaur, Brock C. Christensen
The paper develops a continuous DNA methylation metric (B-Index) to classify CLL subtypes and identifies epigenetic signals linked to B-cell differentiation and tumor burden.
bioRxiv · Sep 16, 2025 · PreprintCancer Biology