Author

Jeffrey R. Hage

Dartmouth CollegeORCID 0009-0008-7221-5680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:imputation· 1

Frequent Co-Authors

Brock C. ChristenseniD· 2 shared Daniel K. SchoolcraftiD· 1 shared Devin C. KoestleriD· 1 shared Fiyinfoluwa Kolawole· 1 shared Fred KollingiD· 1 shared Lauren M. WainmaniD· 1 shared Pauline PatzkeiD· 1 shared Prabhjot KauriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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9 top collaborators · 29 mutual co-author links

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2 shared papersSystems Biology

Brock C. ChristensenORCID

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2 papers

Recent·Most cited

Systems Biologynpj Systems Biology and ApplicationsPeer-reviewedMay 13, 2026

Inferring absolute counts from proportions by constraining multivariate normal distributions

Jeffrey R. Hage, Devin C. Koestler, Brock C. Christensen

This paper introduces MCI, a method to estimate absolute counts from proportional data using multivariate normal distributions, and demonstrates its effectiveness on white blood cell counts and single-cell mRNA data.

DOI 10.1038/s41540-026-00737-9

bulk RNA-seqstatistical model

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Cancer BiologybioRxivPreprintSep 16, 2025

Continuous DNA Methylation Deconvolution-Based Surrogate for B-Cell Differentiation State in CLL

Jeffrey R. Hage, Lauren M. Wainman, Fiyinfoluwa Kolawole…·Brock C. Christensen

The paper develops a continuous DNA methylation metric (B-Index) to classify CLL subtypes and identifies epigenetic signals linked to B-cell differentiation and tumor burden.

DOI 10.1101/2025.09.16.676535

humanDNA methylation

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