Cancer BiologybioRxivPreprint
Continuous DNA Methylation Deconvolution-Based Surrogate for B-Cell Differentiation State in CLL
Jeffrey R. Hage, Lauren M. Wainman, Fiyinfoluwa Kolawole…·Brock C. Christensen
The paper develops a continuous DNA methylation metric (B-Index) to classify CLL subtypes and identifies epigenetic signals linked to B-cell differentiation and tumor burden.
DOI 10.1101/2025.09.16.676535