Targeting cellular senescence alleviates bone marrow aging
Bowen Yan, Jin Han, Yang Yang…·Olga A. Guryanova
This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.
Author
University of Florida HealthORCID 0000-0002-4735-7512Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Bowen Yan, Jin Han, Yang Yang…·Olga A. Guryanova
This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.
Jeffrey R. Hage, Lauren M. Wainman, Fiyinfoluwa Kolawole…·Brock C. Christensen
The paper develops a continuous DNA methylation metric (B-Index) to classify CLL subtypes and identifies epigenetic signals linked to B-cell differentiation and tumor burden.
Bowen Yan, Qingchen Yuan, Prabhjot Kaur…·Olga A. Guryanova
This study shows that Dnmt3a mutations in clonal hematopoiesis drive metabolic diseases like obesity and diabetes in mice, especially under high-fat diet.