Unusual lineage plasticity revealed by YY1 knockout in pro-B cells
Sarmistha Banerjee, Sulagna Sanyal, Suchita Hodawadekar, Sarah Naiyer, Nasreen Bano, Anupam Banerjee, Joshua H. Rhoades, Dawei W. Dong, David Allman, Michael L. Atchison
This study shows that YY1 knockout in pro-B cells leads to lineage plasticity, enabling the generation of T lineage cells and revealing YY1's role in lineage commitment.
bioRxiv · Mar 22, 2024 · PreprintDevelopmental Biology