Michael L. Atchison

This study identifies YY1-dependent miRNA networks that regulate B cell identity and lineage commitment through transcriptional and post-transcriptional mechanisms in pro-B cells.

This study shows that YY1's Polycomb group function is essential for maintaining HSC quiescence and preventing premature aging.

This study shows that YY1 knockout in pro-B cells leads to lineage plasticity, enabling the generation of T lineage cells and revealing YY1's role in lineage commitment.