David Allman

Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells

This study shows Notch2 signaling enhances TLR3 and TLR4 responsiveness in MZ B cells, promoting immune responses to viral and bacterial pathogens.

Mast Cells Enhance Myeloma Engraftment and Promote Bone Destruction in the NSG-hIL6 Patient Derived Xenograft Model

This study shows mast cells enhance myeloma engraftment and promote bone destruction in the NSG-hIL6 xenograft model by secreting factors that improve myeloma cell survival.

The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

Unusual lineage plasticity revealed by YY1 knockout in pro-B cells

This study shows that YY1 knockout in pro-B cells leads to lineage plasticity, enabling the generation of T lineage cells and revealing YY1's role in lineage commitment.

Increased activity of IRE1 improves the clinical presentation of EAE

This study shows that increased IRE1 activity in a mouse model of EAE reduces inflammation and improves motor function, suggesting context-dependent protective effects of ER stress.