PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex
Joshua Pajak, Jacob T. Landeck, Xingchen Liu, Krishna Anand, Sasha Litvak, Brian A. Kelch
The paper presents structures of the yeast clamp loader RFC and shows PCNA facilitates nucleotide exchange by promoting ADP release through subunit separation.
bioRxiv · Jul 2, 2025 · PreprintBiochemistry