Author

Joshua Pajak

University of Massachusetts Chan Medical SchoolORCID 0000-0001-5781-0870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Brian A. KelchiD· 2 shared Gaurav AryaiD· 2 shared Marc C. MoraisiD· 2 shared Paul J. JardineiD· 2 shared Emilio Reyes-Aldrete· 1 shared Erik A. Dill· 1 shared Jacob T. LandeckiD· 1 shared Krishna AnandiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Brian A. KelchORCID

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3 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 3, 2025

Regulation of Ordinal DNA Translocation Cycle in Bacteriophage {varphi}29 through Trans-Subunit Interactions

Rokas Dargis, Joshua Pajak, Pavan Ariyawansa…·Gaurav Arya

This study investigates how the bacteriophage Φ29 DNA packaging motor regulates translocation through trans-subunit interactions, revealing a steric hindrance mechanism involving ATP hydrolysis and DNA gripping.

1 citation

bacteria (other)statistical model

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BiochemistrybioRxivPreprintJul 2, 2025

PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex

Joshua Pajak, Jacob T. Landeck, Xingchen Liu…·Brian A. Kelch

The paper presents structures of the yeast clamp loader RFC and shows PCNA facilitates nucleotide exchange by promoting ADP release through subunit separation.

1 citation

yeaststructural biology

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BiophysicsNucleic Acids ResearchPeer-reviewedMay 28, 2021

Atomistic Basis of Force Generation, Translocation, and Coordination in a Viral Genome Packaging Motor

Joshua Pajak, Erik A. Dill, Emilio Reyes-Aldrete…·Marc C. Morais

The paper presents the first atomic-resolution structure of a viral DNA packaging motor and describes its mechanism through molecular dynamics simulations.

30 citations

virusstructural biology

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