Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease
Rushil Yerrabelli, Asa Thibodeau, Djamel Nehar-Belaid, Radu Marcheş, Sathyabaarathi Ravichandran, Yoann Barnouin, Ranjan Sen, Silke Paust, Michael L. Stitzel, Luigi Ferrucci, Phillip West, Jacques Banchereau, Dennis T. Villareal, George A. Kuchel, Duygu Ucar
This study shows that a 6-month lifestyle intervention reduces ER stress and inflammation while enhancing naive immune cell identity in older adults with metabolic disease.
bioRxiv · May 12, 2026 · PreprintImmunology