Ranjan Sen

The paper develops a proteomic signature, MitoAge, that predicts age-related mitochondrial health based on circulating factors in serum.

This study shows that a 6-month lifestyle intervention reduces ER stress and inflammation while enhancing naive immune cell identity in older adults with metabolic disease.

The paper investigates how genetic variation and selection shape antibody repertoires across B cell development stages, finding distinct roles for genetics and selection in heavy and light chain repertoires.

The paper identifies age-associated DNA methylation sites in immune cells and links them to transcription factor motifs and histone modifications, suggesting adaptive responses to oxygen fluctuations in aging.

The paper reveals that p100 modulates NF-κB responses to TNF by enabling a late RelB:p50 activity that alters gene expression programs.