Jacques Banchereau

The paper maps the human immune system across the lifespan using scRNA-seq and snATAC-seq, revealing unique infant immune signatures and age-related changes in immune cell populations.

This study shows that a 6-month lifestyle intervention reduces ER stress and inflammation while enhancing naive immune cell identity in older adults with metabolic disease.

The paper identifies intron retention in STAT2 as a regulator of immune signaling and a predictor of immunotherapy response in lung cancer.

This study compares immune responses to different COVID-19 vaccines in humans, finding distinct interferon programs in myeloid cells based on vaccine type and dose timing.

The paper uses single-cell profiling to show CMV drives clonal expansion of GZMK CD8 and Th1 cells in humans.

The paper examines TE-driven alternative splicing in breast cancer using long-read RNA sequencing, identifying tumor-specific splicing events and TE-derived isoforms with potential therapeutic implications.

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.

The paper uses long-read RNA sequencing to identify novel isoforms in breast cancer, finding splicing events associated with patient survival.

This paper introduces ATAC-DoubletDetector, a read count-based method to detect multiplets in snATAC-seq data and annotate their cellular origins, achieving 85% accuracy in annotation.

The paper identifies sex-biased differential alternative splicing across multiple human tissues and links it to gene function and estrogen response.

The paper develops a systems-based approach to classify T-cell responses using transcriptome data from PBMCs stimulated with peptides, identifying new molecular patterns and transcription factors involved in antigen-specific responses.