George A. Kuchel

This study links clonal hematopoiesis to accelerated frailty and functional decline across multiple organ systems in humans.

DIANNE enables rapid training and inference of spatial differential attributes in histology images without manual annotations, using mixup augmentation and foundation models.

The paper maps the human immune system across the lifespan using scRNA-seq and snATAC-seq, revealing unique infant immune signatures and age-related changes in immune cell populations.

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

This study shows that a 6-month lifestyle intervention reduces ER stress and inflammation while enhancing naive immune cell identity in older adults with metabolic disease.

This study compares immune responses to different COVID-19 vaccines in humans, finding distinct interferon programs in myeloid cells based on vaccine type and dose timing.

The paper uses single-cell profiling to show CMV drives clonal expansion of GZMK CD8 and Th1 cells in humans.

The paper develops a proteomic signature (HPS) to predict healthspan, showing it predicts mortality and age-related diseases better than other biological age measures.

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

The paper develops a proteomic aging clock (PAC) that predicts all-cause mortality and disease outcomes in middle-aged and older adults using plasma protein data.

This study finds that CYP2C19 loss-of-function variants are associated with increased risk of ischemic stroke and MI in patients on long-term clopidogrel therapy in primary care.

This paper defines the cellular composition of the mouse urinary bladder using single-cell profiling and spatial analysis, identifying novel cell types and fibroblast populations associated with aging.

This paper introduces ATAC-DoubletDetector, a read count-based method to detect multiplets in snATAC-seq data and annotate their cellular origins, achieving 85% accuracy in annotation.

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

The paper re-evaluates the association between ApoE e4e4 genotype and COVID-19 test positivity and mortality in the UK Biobank cohort, finding increased risks for both outcomes compared to e3e3 genotype.

The paper assesses the effects of ApoE e2 variants on aging-related outcomes using UK Biobank data, finding protective effects for e2e3 but not e2e2.

The paper investigates the association between ApoE e4 genotype and severe COVID-19 in the UK Biobank community cohort, finding a link with increased risk of severe outcomes.

This study identifies genetic variants associated with red blood cell distribution width (RDW) in 166,666 UK Biobank volunteers, linking RDW to aging-related pathways and health outcomes.

The study tests a reported healthy ageing gene expression score in two cohorts and finds no association with age or related phenotypes.