Biodistribution-Driven Discovery Identifies a Glycosidase-Cleavable Linker to Reprogram Radiotheranostics
Woong Hee Lee, Sai Reddy Doda, Kwamena E. Baidoo, Divya Nambiar, Joon‐Yong Chung, Stephen Adler, Elijah F. Edmondson, Yuki Ueda, Satoshi Omiya, Xiaoyi Li, Hima Makala, Julia Sheehan‐Klenk, Stanley Fayn, Orit Jacobson, Eric Lindberg, , Freddy E. Escorcia
A β-galactose-cleavable linker reduces kidney toxicity, enhances tumor targeting and therapeutic efficacy in radiopharmaceutical therapy.
bioRxiv · Sep 11, 2025 · PreprintCancer Biology