RNA pull-down-Confocal Nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases α-Synuclein levels
Siran Zhu, Nila Roy Choudhury, Saul Rooney, Nhan T. Pham, Joanna Koszela, David A. Kelly, Christos Spanos, Juri Rappsilber, Manfred Auer, Gracjan Michlewski
The paper introduces RP-CONA, a method to identify RNA-protein interaction modulators, and finds quercetin inhibits HuR-pri-miR-7-1 interaction, increasing miR-7 and reducing α-Synuclein.
Nucleic Acids Research · May 21, 2021Peer-reviewedMolecular Biology