Live-cell assays for cell stress responses reveal new patterns of cell signaling caused by mutations in rhodopsin, α-synuclein and TDP-43
Kevin M. Harlen, Elizabeth C. Roush, Joseph E. Clayton, Scott Martinka, Thomas E. Hughes
The paper uses live-cell assays to study how mutations in rhodopsin, α-synuclein, and TDP-43 affect cell stress and signaling, revealing altered Ca2+ signaling and phosphodiesterase activity.
Frontiers in Cellular Neuroscience · Dec 17, 2019Peer-reviewedNeuroscience