An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer.
Chiara Capitani, Jessica Iorio, Elena Lastraioli, Claudia Duranti, Giacomo Bagni, Ginevra Chioccioli Altadonna, Rossella Colasurdo, Giorgia Scarpellino, Scott P. Fraser, Andrea Becchetti, Mustafa B.A. Djamgoz, Annarosa Arcangeli
This paper identifies an integrin-centered membrane complex in breast cancer cells that regulates f-actin organization and migration through ion transport proteins, with implications for therapeutic targeting of triple-negative breast cancer.
bioRxiv · Jul 2, 2024 · PreprintCancer Biology