Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage
Benjamin Murter, Sean C. Robinson, Hridesh Banerjee, Louis Lau, Uzodinma N. Uche, Andrea L. Szymczak-Workman, Larry Kane
This study identifies mechanisms controlling TrIP downregulation on T cells, showing it depends on TCR signal strength, PKC, and ADAM proteases.
Journal of Biological Chemistry · Oct 23, 2024Peer-reviewedCell Biology