Hridesh Banerjee

T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity

This study shows that T cell-specific loss of IRF1 impairs CD8 T cell activation and antitumor immunity, despite normal cytotoxic T cell numbers.

Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage

This study identifies mechanisms controlling TrIP downregulation on T cells, showing it depends on TCR signal strength, PKC, and ADAM proteases.