Larry Kane

This study shows ATR kinase inhibitors cause mitochondrial fission and impair immune memory in CD8+ T cells during viral infection.

This study shows that T cell-specific loss of IRF1 impairs CD8 T cell activation and antitumor immunity, despite normal cytotoxic T cell numbers.

This study shows that TrIP deficiency in CD8 T cells enhances anti-tumor immunity by increasing inflammatory transcriptional profiles, T cell infiltration, and clonal diversity against tumors.

This study identifies mechanisms controlling TrIP downregulation on T cells, showing it depends on TCR signal strength, PKC, and ADAM proteases.