Author

Sean Fletcher

McGill University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andy Bai· 1 shared Anne‐Marie LauzoniD· 1 shared Christie Liu· 1 shared Esther E. BiswasiD· 1 shared Linda KachmariD· 1 shared Matheus L. C. SchultziD· 1 shared Subhasis B. BiswasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperBiophysics

Andy Bai

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2 papers

Recent·Most cited

De Novo Design and Computational Validation of a High-Affinity Peptide Inhibitor Targeting the HPV E1-E2 Interface

Sean Fletcher, Esther E. Biswas, Subhasis B. Biswas

This paper designs and validates a high-affinity peptide inhibitor targeting the HPV E1-E2 interface using computational methods, showing improved binding affinity and safety.

bioRxiv · Jun 4, 2026 · PreprintBioinformatics

Molecular mechanics of smooth muscle contraction and relaxation modulated by caldesmon

Matheus L. C. Schultz, Linda Kachmar, Christie Liu, Andy Bai, Sean Fletcher, Anne‐Marie Lauzon

This study measures the molecular effects of caldesmon on smooth muscle myosin force generation and relaxation using a laser-trap assay, showing CaD inhibits force and accelerates relaxation.

bioRxiv · Mar 25, 2026 · PreprintBiophysics