Author

Sean H. White

McMaster University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:protein structure prediction· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jennifer Howe· 3 shared Karun Kar SinghiD· 3 shared Stephen W. SchereriD· 3 shared Alina Piekna· 2 shared Deivid C. RodriguesiD· 2 shared Éric DeneaultiD· 2 shared James EllisiD· 2 shared Muhammad FaheemiD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Jennifer Howe

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Author profile →

3 papers

Recent·Most cited

Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

Chad O. Brown, Jarryll A. Uy, Nadeem Murtaza, Elyse Rosa, Alexandria Alfonso, Sansi Xing, Biren M. Dave, Savannah Kilpatrick, Annie A. Cheng, Sean H. White, Jennifer Howe, Stephen W. Scherer, Yu Lu, Karun Kar Singh

This study examines how different SCN2A de novo variants affect human neuron development and function using patient-derived iPSCs.

Frontiers in Cellular Neuroscience · Jan 15, 2024Peer-reviewedNeuroscience

CNTN5-/+ or EHMT2-/+ iPSC-Derived Neurons from Individuals with Autism Develop Hyperactive Neuronal Networks

Éric Deneault, Muhammad Faheem, Sean H. White, Deivid C. Rodrigues, Song Sun, Wei Wei, Alina Piekna, Tadeo Thompson, Jennifer Howe, Leon Chalil, Vickie Kwan, Susan Walker, Peter Pasceri, Frederick P. Roth, Ryan K. C. Yuen, , Stephen W. Scherer

The paper models ASD-related variants in iPSC-derived neurons and finds hyperactive neuronal networks in CNTN5-/+ and EHMT2-/+ lines.

eLife · Feb 11, 2019Peer-reviewedNeuroscience

Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons

Éric Deneault, Sean H. White, Deivid C. Rodrigues, P. Joel Ross, Muhammad Faheem, Kirill Zaslavsky, Zhuozhi Wang, Roumiana Alexandrova, Giovanna Pellecchia, Wei Wei, Alina Piekna, Gaganjot Kaur, Jennifer Howe, Vickie Kwan, Bhooma Thiruvahindrapuram, , Stephen W. Scherer

This study uses CRISPR to knockout 10 ASD-related genes in iPSCs, revealing reduced functional connectivity in neurons despite diverse gene functions.

Stem Cell Reports · Nov 1, 2018Peer-reviewedNeuroscience