Author

Biren M. Dave

University Health NetworkORCID 0000-0002-1072-1886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

Peter B. DirksiD· 2 shared Ahmed M. AmaniD· 1 shared Alexandria Alfonso· 1 shared Anna Tymofyeyeva· 1 shared Annie A. Cheng· 1 shared Chad O. Brown· 1 shared Chunying Yu· 1 shared Connor S. ChartoniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

Peter B. DirksORCID

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Author profile →

3 papers

Recent·Most cited

Convergence on BRAF and MAPK Signaling in Glioma Development in a P53-ENU model

Kinjal Desai, Anna Tymofyeyeva, Margaret M. Javier, Nataliia Svergun, Vincent Chen Ye, Garrett Bullivant, Jannine Forst, Matthaeus A. Ware, Michelle M. Kushida, Lilian Lee, Chunying Yu, Heather Whetstone, Ryan J. Ward, Biren M. Dave, Ahmed M. Aman, Peter B. Dirks

This study develops a mouse model of pediatric gliomas and identifies BRAF and MAPK signaling as critical drivers of tumor progression and therapeutic resistance.

bioRxiv · Feb 23, 2026 · PreprintCancer Biology

Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

Chad O. Brown, Jarryll A. Uy, Nadeem Murtaza, Elyse Rosa, Alexandria Alfonso, Sansi Xing, Biren M. Dave, Savannah Kilpatrick, Annie A. Cheng, Sean H. White, Jennifer Howe, Stephen W. Scherer, Yu Lu, Karun Kar Singh

This study examines how different SCN2A de novo variants affect human neuron development and function using patient-derived iPSCs.

Frontiers in Cellular Neuroscience · Jan 15, 2024Peer-reviewedNeuroscience

Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis

Biren M. Dave, Xin Chen, Fraser P. McCready, Connor S. Charton, Rachel M. Morley, Jignesh K. Tailor, James Ellis, Xi Huang, Peter B. Dirks

This study differentiates human hindbrain neuroepithelial stem cells into cerebellar granule neurons in vitro, recapitulating key progenitor states and showing SHH's role in lineage specification and maturation.

Development · Jun 29, 2023Peer-reviewedDevelopmental Biology