Programming Brain Cell-Type-Selective Delivery In Vivo with Transporter-Guided Therapeutics
Roshan W. Gunasekara, Lejie Zhang, Lei Tong, John Zhou, Hoang Kim Trinh, Sean Pinon, Madison Gendreau, Emily Scott, John Chiari, Jaime Grutzendler
The paper develops ExACT, a platform for cell-type-selective drug delivery using transporters, showing selectivity for brain cell types and demonstrating its application with antisense oligonucleotides and small-molecule drugs.
bioRxiv · Jun 18, 2026 · PreprintBioengineering