Jaime Grutzendler

Programming Brain Cell-Type-Selective Delivery In Vivo with Transporter-Guided Therapeutics

The paper develops ExACT, a platform for cell-type-selective drug delivery using transporters, showing selectivity for brain cell types and demonstrating its application with antisense oligonucleotides and small-molecule drugs.

TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain

This study shows that TREM2 and APOE do not affect microglia phagocytosis of dying neurons in live mouse brains, but TREM2 influences microglia migration near amyloid plaques.

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease

The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.

Single-cell in vivo brain optogenetic stimulation by two-photon excitation fluorescence transfer

This paper introduces a method to enhance two-photon optogenetic stimulation in live mouse brains by using fluorescent molecules to improve opsin activation efficiency.

Aberrant axonal pathfinding and exuberant myelination in an inducible model of neocortical heterotopia

This study develops an inducible mouse model of neocortical heterotopia and identifies aberrant axonal pathfinding and hypermyelination associated with these ectopic neuronal clusters.

Flexible Learning-Free Segmentation and Reconstruction for Sparse Neuronal Circuit Tracing

This paper introduces a fast, learning-free method for sparse segmentation and reconstruction of neural volumes, demonstrating high-quality results across multiple imaging modalities.