Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology
Heather K. Macpherson, Roger B. Varela, Sebastian McCullough, Tristan Houghton, Isha Chawla, Ning Wang, Venea Dara Daygon, Xiaoying Cui, Susannah J. Tye
This study investigates the effects of unpredictable circadian disruption on locomotor activity and molecular markers in rats, finding biphasic behavioral changes and altered inflammatory, stress, and metabolic profiles.
bioRxiv · Sep 6, 2025 · PreprintNeuroscience