Susannah J. Tye

This study investigates the effects of unpredictable circadian disruption on locomotor activity and molecular markers in rats, finding biphasic behavioral changes and altered inflammatory, stress, and metabolic profiles.

This study uses transcriptomics to investigate melatonin's role in bipolar disorder, finding dysregulated melatonin-related genes and potential therapeutic agents.

This study shows melatonin reduces oxidative stress and metabolic changes caused by IL-6 and dopamine in SH-SY5Y cells, suggesting potential therapeutic effects for bipolar disorder.

This study investigates the anti-manic effects of VTA deep brain stimulation in a methamphetamine-induced mania model, showing both stimulation patterns reduce hyperlocomotion and modulate dopamine dynamics.

This study investigates how chronic ACTH treatment induces anhedonia-like behavior in rats by altering peripheral inflammation and central dopamine dynamics, with limited reversal by bupropion.