Author

Roger B. Varela

The University of QueenslandORCID 0000-0002-7995-5904Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:rat· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Susannah J. TyeiD· 4 shared Heather K. MacphersoniD· 3 shared Tristan Houghton· 3 shared Venea Dara DaygoniD· 3 shared Xiaoying CuiiD· 2 shared Abbas Z. KouzaniiD· 1 shared Charles D. BlahaiD· 1 shared Isha ChawlaiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersNeuroscience

Susannah J. TyeORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology

Heather K. Macpherson, Roger B. Varela, Sebastian McCullough, Tristan Houghton, Isha Chawla, Ning Wang, Venea Dara Daygon, Xiaoying Cui, Susannah J. Tye

This study investigates the effects of unpredictable circadian disruption on locomotor activity and molecular markers in rats, finding biphasic behavioral changes and altered inflammatory, stress, and metabolic profiles.

bioRxiv · Sep 6, 2025 · PreprintNeuroscience

Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells

Heather K. Macpherson, Roger B. Varela, Venea Dara Daygon, James P. Kesby, Xiaoying Cui, Susannah J. Tye

This study shows melatonin reduces oxidative stress and metabolic changes caused by IL-6 and dopamine in SH-SY5Y cells, suggesting potential therapeutic effects for bipolar disorder.

bioRxiv · Sep 3, 2025 · PreprintMolecular Biology

Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Roger B. Varela, Suelen Lucio Boschen, Nathanael James Yates, Tristan Houghton, Charles D. Blaha, Kendall H. Lee, Kevin E. Bennet, Abbas Z. Kouzani, Michael Berk, João Quevedo, Samira Silva Valvassori, Susannah J. Tye

This study investigates the anti-manic effects of VTA deep brain stimulation in a methamphetamine-induced mania model, showing both stimulation patterns reduce hyperlocomotion and modulate dopamine dynamics.

Bipolar Disorders · Apr 1, 2024Peer-reviewedNeuroscience

The role of IL-6 in dopamine dysregulation underlying anhedonia phenotype in rats

Roger B. Varela, Heather K. Macpherson, Tristan Houghton, Venea Dara Daygon, Susannah J. Tye

This study investigates how chronic ACTH treatment induces anhedonia-like behavior in rats by altering peripheral inflammation and central dopamine dynamics, with limited reversal by bupropion.

bioRxiv · Nov 21, 2023 · PreprintNeuroscience