Opioid withdrawal abruptly disrupts amygdala circuit function by reducing peptide actions
Gabrielle C. Gregoriou, Sahil Patel, Sebastian Pyne, Bryony L. Winters, Elena E. Bagley
The paper shows opioid withdrawal reduces peptide activity in the amygdala by increasing neprilysin via PKA, disrupting synaptic transmission and potentially leading to compulsive drug use.
Journal of Neuroscience · Feb 13, 2023Peer-reviewedNeuroscience